1.AAV病毒载体有CMV（全身表达）、CAG（全身表达）、TBG（肝脏特异性）、Insulin（胰岛Beta细胞特异性）、CK8（肌肉特异性）、tMCK（肌肉特异性）、Adiponectin（脂肪细胞特异性）、Syn(神经特异性)、CaMKIIa(神经特异性)等，根据需要可包装对特定组织或细胞感染的AAV，用于表达目的基因。

　　2.荧光蛋白标记载体：具有表达GFP、mCherry等AAV表达载体。

　　3.具有靶向编辑基因AAV载体系统：CRISPR/Cas9（sgRNA）介导的基因编辑系统和shRNA介导的基因敲减系统。

参考文献

1. Wang RR et al, (2022) Dietary intervention preserves β cell function in mice through CTCF-mediated transcriptional reprogramming. Journal of Experimental Medicine. IF: 14.41, (AAV)

2. Qiao J et al (2022) A distinct role of STING in regulating glucose homeostasis through insulin sensitivity and insulin secretion. PNAS. IF=11.2, (AAV)

3. Ji F et al (2022) Blocking hepatocarcinogenesis by a cytochrome P450 family member with female-preferential expression. Gut. IF=23, (AAV)

4. Ma XR et al (2022) Restoring nuclear entry of Sirtuin 2 in oligodendrocyte progenitor cells promotes remyelination during ageing. Nature Communications. IF=14.9, (慢病毒)

5. Wang RR et al, (2022) Dietary intervention preserves β cell function in mice through CTCF-mediated transcriptional reprogramming. Journal of Experimental Medicine. IF: 14.41, (AAV)

6. Xu Z et al, (2022) Disuse-associated loss of the protease LONP1 in muscle impairs mitochondrial function and causes reduced skeletal muscle mass and strength. Nature Communications. IF: 14.9, (AAV)

7. He S et al, (2021) IRE1α regulates skeletal muscle regeneration through Myostatin mRNA decay. J Clin Invest. IF: 15.86, (AAV)

8. Wang J et al, (2021) Leukocyte cell-derived chemotaxin 2 promotes the development of nonalcoholic fatty liver disease through STAT-1 pathway in mice. Liver International. IF: 5.17, (AAV)

9. Liu T et al, (2020) BAF60a deficiency uncouples chromatin accessibility and cold sensitivity from white fat browning. Nature Communications. IF=12.35, (逆转录病毒, AAV)

10. Hu Z et al, (2019) CREBZF as a key Regulator of STAT3 Pathway in the Control of Liver Regeneration in Mice. Hepatology. IF=14.08, (腺病毒，AAV)

11. Wang X et al, (2019) The zinc transporter Slc39a5 controls glucose sensing and insulin secretion in pancreatic β-cells via Sirt1- and Pgc-1α-mediated regulation of Glut2. Protein Cell. IF=6.228, (腺病毒)

12. Liu L et al, (2019) Coupling of COPII vesicle trafficking to nutrient availability by the IRE1α-XBP1s axis. PNAS. June 11; 116 (24) 11776-11785. IF=9.504, (AAV，腺病毒)

13. Li Y et al, (2019) MiR-223 is essential for maintaining functional β-cell mass during diabetes through targeting unique bipartite Foxo1 and Sox6 pathways. Journal of Biological Chemistry. IF=4.01, (腺病毒)

14. Zhao XY et al, (2018) Long noncoding RNA licensing of obesity-linked hepatic lipogenesis and NAFLD pathogenesis. Nature Communications. IF=12.35, (AAV，腺病毒)

15. Zhang F et al, (2018) Hepatic CREBZF Couples Insulin to Lipogenesis by Inhibiting Insig activity and Contributes to Hepatic Steatosis in Diet-Induced Insulin-Resistant Mice. Hepatology. IF=14.079, (腺病毒)

16. Guo L et al, (2017) Hepatic neuregulin 4 signaling defines an endocrine checkpoint for steatosis-to-NASH progression. J Clin Invest. IF=12.28, (腺病毒，AAV)

17. Meng ZX et al, (2018) Uncoupling exercise bioenergetics from systemic metabolic homeostasis by conditional inactivation of Baf60s in skeletal muscle. Diabetes. IF: 7.72, (逆转录病毒, 腺病毒)

18. Zhang D et al, (2017) Lipogenic transcription factor ChREBP mediates fructose-induced metabolic adaptations to prevent hepatotoxicity. J Clin Invest. IF=12.28, (腺病毒)

19. Meng ZX et al, (2017) Glucose sensing by skeletal myocytes couples nutrient signaling to systemic homeostasis. Molecular Cell. IF: 15.58, (逆转录病毒, 腺病毒)